Fig. 2

Over-represented HLA class I and II peptides in ccRCC. a Upper plot: the x-axis shows all HLA class I-presented peptides identified by HLA ligandomics in ccRCC tissues of patient cohort I. The y-axis shows the percentage of samples with the respective peptides. Peptides detected in tumor tissue are plotted as positive percentages in red, and peptides detected on non-tumor tissues are plotted in negative percentages in green. The light blue shaded area represents the tumor exclusivity, where 100% indicates ccRCC-specific presentation. Lower plot: percentages of peptides detected in non-tumor tissues, comprising tumor-paired non-tumor kidney tissue (patient cohort I, n = 55) and healthy tissue samples from various organs (n = 158), related to all peptides detected in proliferation reagentccRCC tissue of cohort I. b The same presentation for HLA class II-presented peptides