Fig. 5

Functional associations of candidate target genes. a DAVID GO analysis of the candidate genes. Plotted are the Bonferroni (BF) corrected p values of the enrichment. The colors of the dots represent the enrichment fold changes. b Circular bar graph of biological functions assigned to the candidate genes by PANTHER GO analysis. c Correlations of candidate genes with tumor metabolites. Plotted are the medians and ranges of Pearson’s correlation coefficients of the candidates with the metabolites of the indicated metabolite classes (Additional file 2: Tab. S4). Only significant (p < 0.05) correlations with median correlation coefficients of ≥ 0.3 are plotted. d Correlation of candidate genes with immuno-oncological processes. An overview of markers descriptive of the processes is given in Additional file 2: Tab. S5. Plotted are the medians and ranges of Pearson’s correlation coefficients if the candidate genes correlated with a coefficient of ≥ 0.3 in at least 25% of samples. e Overview of the final 113 candidates. The color range indicates for each of the plotted parameters the respective values. Exact values can be retrieved from Additional file 2: Tab. S10