Fig. 1

Copy number profile comparison between the liquid (LB) and solid biopsy (SB) of patient 17. a Copy number profile of the LB (top) and SB (bottom). Dots represent bins, whereas horizontal white lines indicate segments, covering bins of expected equal copy number. b Overlap plot derived from a smoothing sliding window, which interpolates the average of 100 enclosed bins to its central position. c Correlation scatter plot, using previous smoothened values. The solid line indicates identity (y = x), whereas the dotted line results from a total least squares analysis. A steeper dotted than solid line shows that the tumor fraction is higher in the SB. The Pearson correlation coefficient (r) is given