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Fig. 3 | Genome Medicine

Fig. 3

From: Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma

Fig. 3

Overview of aberrations detected using liquid biopsies (LBs) in comparison to public data. Colored waves represent fractions of aberrant LBs per histological subtype. Patterns above the x-axes indicate gains, whilst opposite contours represent losses. The dendrogram (left) results from agglomerative complete-linkage clustering applied to the Pearson distances (i.e., d = (1 − r)/2) between these waves (vectors defined as %gains–%losses). Line graphs represent smoothened mean log2 ratios for LBs (thick solid) and the used large public dataset (thin dotted) [16]. The Pearson correlation (r) between these lines is given. Horizontal gray bars below and above each profile hold subtype-specific aberrant loci according to public data [16]

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