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Table 3 Number of significant sites (FDR < 0.05) on chromosomes X and 20 by cohort with replication and validation results

From: Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples

 Chromosome XChromosome 20
BothMaleFemaleBothMaleFemale
LSADT
 Hypermethylated1494348973343071371
 Hypomethylated1010346276272936
 % hypermethylated93.7180.8266.0081.4691.9231.83
MADT
 Hypermethylated3254668877343601443
 Hypomethylated908862397496691359
 % hypermethylated78.3134.4778.7749.4934.9951.50
LSADT-MADT
 Replicated55123293204361346
  % LSADT34.5922.9121.5649.7610.7831.25
  % MADT13.259.1026.0213.763.5048.04
 Hypergeometric test p7.89e−463.30e−673.22e−1055.42e−1572.69e−110
LBC validation
 Number validated (FDR < 0.05)*31624351590
 % validated5.4513.018.1917.1641.476.69
 LBC FDR < 0.0531459127816111180565
  1. *FDR from testing all CpGs on chromosomes X or 20 in LBC1921 birth cohort