Table 3 Number of significant sites (FDR < 0.05) on chromosomes X and 20 by cohort with replication and validation results

From: Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples

	Chromosome X			Chromosome 20
	Both	Male	Female	Both	Male	Female
LSADT
Hypermethylated	149	434	897	334	307	1371
Hypomethylated	10	103	462	76	27	2936
% hypermethylated	93.71	80.82	66.00	81.46	91.92	31.83
MADT
Hypermethylated	325	466	887	734	360	1443
Hypomethylated	90	886	239	749	669	1359
% hypermethylated	78.31	34.47	78.77	49.49	34.99	51.50
LSADT-MADT
Replicated	55	123	293	204	36	1346
% LSADT	34.59	22.91	21.56	49.76	10.78	31.25
% MADT	13.25	9.10	26.02	13.76	3.50	48.04
Hypergeometric test p	7.89e−46	3.30e−67	3.22e−105	5.42e−157	2.69e−11	0
LBC validation
Number validated (FDR < 0.05)*	3	16	24	35	15	90
% validated	5.45	13.01	8.19	17.16	41.47	6.69
LBC FDR < 0.05	314	591	2781	611	1180	565

*FDR from testing all CpGs on chromosomes X or 20 in LBC1921 birth cohort

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