Fig. 5

Sense transcription of intronic EREs is the main source of ereMAPs. a Boxplot showing the mean expression levels (log₁₀(TPM + 1)) of ERE families that are source or non-source of ereMAPs in B-LCLs (Mann-Whitney test, ***P ≤ 0.001). b Barplot showing the number of ereMAPs generated by sense or antisense transcription of ERE sequences. c Stacked barplot depicting the proportions of LINE, LTR, and SINE groups in the genome, transcriptome, and immunopeptidome. Statistical significance was computed with a chi-squared test (**P ≤ 0.01). d Pie charts depicting the percentages of all ERE sequences (left) and of ereMAP-coding sequences (right) that are localized in intergenic regions, introns, or coding sequences (chi-squared test, ***P ≤ 0.001). e Scatterplot showing the Kendall tau correlation between the number of ereMAPs generated by each ERE family and the number of copies of the ERE family’s sequence in the human genome based on RepeatMasker annotations