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Fig. 1 | Genome Medicine

Fig. 1

From: Polygenic risk scores: from research tools to clinical instruments

Fig. 1

Normal distribution of polygenic risk scores, for a disorder of prevalence 20% (prev), with cases having a mean PRS of t = 0.3. Black line: population N(0,1) distribution. Grey shaded area: controls, unaffected with disorder, with mean PRS = − prev × t/(1 − prev) = − 0.075. Red shaded area: cases, mean PRS t = 0.3. AUC = 0.605, calculated from Φ (Cohen’s d/√2), where Φ is the normal distribution cumulative distribution function, and Cohen’s d is the difference between mean PRSs for cases and controls [8]

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