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Fig. 2 | Genome Medicine

Fig. 2

From: Ancestry-specific predisposing germline variants in cancer

Fig. 2

Ancestry-specific predisposing germline variants. Predisposing variants in the significant (regression analysis; a) and suggestive (rare variant burden testing; b) cancer-gene associations are shown. The variants are labeled with carrier counts and colored by their respective carriers’ ancestry (European Ancestry: blue, African ancestry: red, East Asian Ancestry: green). a Significant predisposing variants identified in the African and East Asian ancestries are shown across respective cancer types. For BRCA2, predisposing variants across all cancers are shown (top) in comparison with the two cancer types with significant associations in the African ancestry (LUSC and OV, bottom). Similarly, predisposing variants contributing to the significant association of BRIP1 in STAD in the East Asian ancestry are shown. b Suggestive predisposing variants identified in the African ancestry are shown for ATM, FH, and VHL genes within their associated cancer types. Bi-allelic events in each carrier are linked by a grey line bracket where the somatic second-hit mutations are marked with a box. c Borderline-suggestive predisposing variants identified in the East Asian ancestry are shown for RECQL in STAD and POLE in LIHC

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