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Fig. 3 | Genome Medicine

Fig. 3

From: Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer

Fig. 3

Subnetworks identified by NETPHIX. Panel for each signature consists of a network view of a module (left) and a heatmap showing an association of module gene alterations with signature strength across patients (right). The network node size indicates the gene robustness (regarding NETPHIX results for different random initialization runs of SIGMa), while the darkness of red color represents its individual association score (empirical pvalue based on phenotype permutation test). Each heatmap shows the number of mutations attributed to a given signature for all patients (orange; top row; log10 scale) sorted from low to high (columns). For each gene in the module, gene alteration information observed in each patient is shown in gray, while patients not altered are in white. The last row shows the alteration profile of the entire subnetwork in black. Only subnetworks significant in phenotype associations for mutational Signatures 2C, 2D, 13C, 13D, 3C, 3D, and 8C are shown; results for Signatures 1D and 5D were not significant

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