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Fig. 3 | Genome Medicine

Fig. 3

From: The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissues

Fig. 3

Rate of somatic mutations varies significantly across the 46 tissues of the GTEx cohort (ignoring kidney, cell-EBV-transformed lymphocytes, and cell-transformed fibroblasts for technical reasons, see the “Methods” section). a Distribution of the somatic mutation rate per base and individual residuals (mutRate residuals) across analyzed tissues. mutRate residuals represent the somatic mutation rates corrected for non-biological confounders such as PCR duplication rate, RIN, cohort, and read coverage. b Spearman correlation between mutRate residuals and age per tissue. Colors show the significance of the correlation test after FDR correction (q value < 0.05 in red)

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Genome Medicine

ISSN: 1756-994X

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