Fig. 1
From: Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
ATAC-see identifies chromatin accessibility changes in HGPS fibroblasts. a ATAC-see reveals loss of highly accessible chromatin foci in malformed HGPS nuclei. Scale bar = 10 μm. b Quantification of cells with three or more ATAC-see foci (P = 1.43e−2, unpaired t-test). Fifty nuclei were counted per sample (three replicates). c Correlation of the number of cells with three or more ATAC-see foci with the number of cells with malformed nuclei (HGPS: R2 = 0.30). Malformed nuclei were quantified as in b