ATAC-seq reveals an enrichment of chromatin accessibility changes in lamina-associated domains (LADs). a Regions gaining (n = 397) or losing (n = 148) accessibility in HGPS compared with controls (q < 0.05, Benjamini-Hochberg). b Distribution of ATAC-seq peaks across genes, promoters and enhancers. c Distribution of ATAC-seq peaks across lamin A-, lamin B-, and non-LAD-associated regions (*P < 0.05, Fisher’s exact test). d HOMER transcription factor motif enrichment analysis reveals that members of the AP1 family are highly enriched (q < 0.01, Benjamini-Hochberg) in differentially accessible regions. Motif densities were calculated using the HOMER motif density tool for the top de novo motifs.