Fig. 5
From: Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Epigenetic deregulation is accompanied by intranuclear relocalization in HGPS. a Representative EDIL3 FISH images in HGPS and control nuclei. A telomeric probe (red) on Chr5 was used as a positive staining control. The distance from the FISH signal to the nuclear periphery was measured in the focal plane in cells exhibiting a clear biallelic signal. b, c Quantification of a for EDIL3 and IGFBP7 loci in two control and three HGPS cell lines for 60 cells per sample. EDIL3: P = 3.03e−08, Welch’s two-sample t-test. IGFBP7: P = 2.75e−13, Welch’s two-sample t-test