Fig. 3
From: A comparison of epigenetic mitotic-like clocks for cancer risk prediction
Epigenetic mitotic clock rate estimates in precancerous inflammatory conditions. a Left panel: Estimated stem cell division rate (SCDR) from epiTOC2 (y-axis) against the progression stage in gastric metaplasia (x-axis, N = normal gastric mucosa, MildIM = mild intestinal metaplasia, IM = advanced intestinal metaplasia). The number of samples in each group is indicated. P value at top, denoted by P(LR), is derived from a linear regression of SCDR against progression stage. Other P values derive from one-tailed Wilcoxon-rank sum tests comparing neighboring progression stages. Right panel: ROC curve, AUC value, and 95% confidence interval for SCDR discriminating normal from metaplasia (MildIM+IM). b As a, but now for a study profiling DNAm in normal colon (N) and colorectal adenoma (A). ROC and AUC show ability of estimated SCDR to discriminate N from A. c, d As a, b but for the HypoClock model