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Fig. 1 | Genome Medicine

Fig. 1

From: Angiosarcoma heterogeneity and potential therapeutic vulnerability to immune checkpoint blockade: insights from genomic sequencing

Fig. 1

Distribution of mutations identified in the cohort of 48 angiosarcoma samples (The Angiosarcoma Project—https://ascproject.org/). a Number of mutations per sample in the Angiosarcoma Project collection of 48 tumors (mean = 260 mutations/sample); the mean in the subgroup of face and scalp angiosarcoma is 925 mutations/sample (N = 11 samples). In comparison, the mean number of mutations per sample in The Cancer Genome Atlas (TCGA) pan-cancer cohort is 212 mutations/sample (N = 10,106 samples; p value = 0.019), in the sarcoma cohort is 74 mutations/sample (N = 235 samples; p value = 0.008), in the melanoma cohort is 742 mutations/sample (N = 441 samples; p value = 0.496), and in the Angiosarcoma Project non-face/non-scalp subgroup is 63 mutations/sample (N = 37 samples; p value = 0.007). bd Classification of mutations observed in 48 angiosarcoma samples by physicochemical properties (nucleotide, mutation types, and amino acid changes). A total of 12,499 variants were analyzed. Hydrophobicity increase reflects greater immunogenicity, as described by [13,14,15]

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