Fig. 1

Overview of the study. a In total, 101 subjects were included in the study. The upper part shows the number of individuals that came to each of the six visits (red, blue, green, purple, orange, and gray). The lower part shows the distribution of each visit for the subjects that completed the program across 2 years. b The rectangular plot shows the types of data that is collected in the study; see more details in Table S2. c The MDS plot shows the pairwise genetic distances between 101 subjects based on the whole genome sequencing. The color code indicates the origin of the parents of each individual (upwards triangle, mother; inverted triangle, father)