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Fig. 2 | Genome Medicine

Fig. 2

From: Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort

Fig. 2

Longitudinal plasma protein profiling. a The distribution of the Log2 fold change of protein concentration per sample versus the average protein concentration level with FDA approved drug targets highlighted. b The inter-individual and intra-individual variation of protein levels calculated as the coefficient of variation (CV) for each protein within each visit and across all analyzed individuals (n = 90), and as the mean CV for each protein within each individual across all visits (n = 6), respectively, colored by the median concentration level of protein. The protein concentration variation across visits one to six, with each individual connected with a dotted line for c growth hormone 2 (GH2) and d RAS p21 protein activator 1 (RASA1). The color code indicates females and males. e Hierarchical clustering based on pairwise Pearson correlation distance of the protein concentration in all 540 samples is shown with labels color coded by individual (see more details in Fig.S3). f Violin plot showing the distribution of inter- and intra-individual Pearson correlation for all samples. g Ternary plot based on two-factor ANOVA for all proteins, assessing the relative effect of the inter-individual variation, visits, and residuals. The color code indicates the median concentration level of protein

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