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Fig. 3 | Genome Medicine

Fig. 3

From: Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort

Fig. 3

Global analysis of the genetic regulation of the proteome. a Chord diagram showing the distributions of cis- and trans-pQTLs in 23 chromosomes. Each link represents cis- or trans-pQTLs in a chromosome, respectively, with the ribbon width reflecting the number of pQTLs. b Genomic locations of the pQTL variants and the associated proteins, colored by cis- and trans-pQTLs. c The fractions of cis- and trans- pQTLs in different types of genomic regions. d Manhattan plot of the sentinel pQTL per protein. The color code indicates the cis- and trans-pQTLs for the 107 proteins with significant associations, and the gray dots represent the none significant associations

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