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Fig. 4 | Genome Medicine

Fig. 4

From: Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort

Fig. 4

Examples of three proteins with the top most significant pQTLs. a Manhattan plot of protein FOLR3 shows the genome locations of all associated pQTLs. b Bee-swarm and box plot of protein FOLR3 shows the association between genotype of rs71891516 with median concentration of FOLR3. c The longitudinal protein concentration across visits one to six with each individual connected with a dotted line for FOLR3. d Manhattan plot for protein PDGFR3. e Bee-swarm and box plot showing the associations between genotype of rs3816018 with median concentration of PDGFRB. f Longitudinal protein concentration levels of PDGFR3. g Manhattan plot for protein MEP1B. h Bee-swarm and box plot showing the associations between genotype of rs3816018 with median concentration of MEP1B. i Longitudinal protein concentration levels of MEP1B. The color indicates the genotypes of rs71891516, rs3816018 and rs620982, respectively

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