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Fig. 6 | Genome Medicine

Fig. 6

From: Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort

Fig. 6

Dynamic molecular profiling changes and impact on weight loss and infection. a Chord diagram of the 50 most significant proteins related to body composition (bioimpedance fat, bioimpedance muscle, bioimpedance bone, weight, waist and BMI). The size of the link is defined as the absolute value of coefficient of the corresponding effect, and proteins are sorted based on the coefficient calculated using mixed-effect modeling. b A radar plot showing the protein profiles of the 37 most significant proteins positively related to body composition for the subject W0010 who had a 15.4 kg weight loss in 3 months between 3 and 4 and a total weight loss of 16.6 kg during the 2 years. c Chord diagram of the 50 most significant proteins related to CRP and including top six other parameters with significant effect to the same proteins. The size of the link is defined as the absolute value of coefficient of the corresponding effect and proteins are sorted based on the coefficient calculated using mixed-effect modeling. d Radar plots of the positively correlated proteins (n = 44) showing the relative abundance level in subject W0022 who had an increased CRP of 79 between visit 1 and 2

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