Fig. 4

Example boxplots of significant correlations between RMS values (root mean square values measuring contractile response) and transcript levels. Spearman correlations were performed using RMS values and expression data from individuals with (N = 13) and without (N = 50) asthma separately. Only nine tests survived correction for multiple testing, and all were among ASMCs from donors with a history of asthma; six are shown here (UAP1, UDP-N-acetylglucosamine pyrophosphorylase 1; DDX20, DEAD-box helicase 20; SH3GL3, endophilin A3; WNK2, WNK lysine deficient protein kinase 2; GRIA1, glutamate ionotropic receptor AMPA type subunit 1; BNIP3, BCL2 interacting protein 3). P values in controls are shown along the bottom of each plot. Expression levels of the transcripts noted are shown on the Y-axis, and RMS values are plotted on the X-axis