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Table 3 Airway smooth muscle QTLs are enriched for asthma GWAS SNPs. Results of enrichment testing for molecular QTLs (lfsr < 0.05), cellular QTLs (P < 0.01), and BRI GWAS SNPs (P < 0.01) among GWAS SNPs with small P values (P < 0.01) using GARFIELD [37]

From: Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma

GWAS (Pividori et al. [16]) Enrichment P valuea GWAS P value thresholdb Fold enrichment Number of lead SNPs
A) Adult-onset asthma (26–65 years) (21,564 cases and 318,237 controls) 0.38 0.01 0.87 59
0.88 0.001 0.95 12
0.38 1 × 10−4 0.41 1
B) Childhood-onset asthma (< 12 years) (9433 cases and 318,237 controls) 9.96 × 10−5 0.01 1.57 99
0.0031 0.001 2.06 31
0.0018 1 × 10−4 2.62 13
  1. aRefers to the P value of the enrichment at the corresponding GWAS P value threshold (third column)
  2. bThe three significant enrichments (i.e., at GWAS P value thresholds of 0.01, 0.001, and 1 × 10−4) in the childhood-onset asthma GWAS are shown; the same three thresholds are shown for the adult-onset GWAS for comparison, despite the lack of significant enrichments