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Fig. 2 | Genome Medicine

Fig. 2

From: Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes

Fig. 2

A schematic demonstrating our approach to identify SARS-CoV-2‚ÄČT cell epitopes and their validation. (a) A diagram of the SARS-CoV-2 virus, listing example proteins. (b) Applying our HLA-I and HLA-II binding predictors to the 13 annotated ORFs of SARS-CoV-2 (including ORF9b). (c) Both HLA-I and HLA-II epitopes are ranked by their likelihood to bind a particular HLA allele. (d) Epitopes shared between SARS-CoV-2 and other coronaviruses which were previously assayed are used for validation. (e) A description of a T cell induction assay to assess immunogenicity of select epitopes

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