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Fig. 4 | Genome Medicine

Fig. 4

From: Modeling and analysis of Hi-C data by HiSIF identifies characteristic promoter-distal loops

Fig. 4

The application of HiSIF in Hi-C data in ERα + breast cancer sensitive cells MCF7 and resistant cells MCF7-TamR. a The Venn diagram of SIFs of MCF7 and MCF7-TamR. There are two numbers in the regions separated with red dash lines because the overlapped regions have different numbers of SIFs in various cells. b The diagram representing two categories of promoter-distal loops (PDLs) of the promoter-containing SIFs according to their distance relative to the TSS of the promoter and whether the non-promoter end is closest to the same gene (P1D1 or P1D2). The promoter region (P1/P2) was defined as − 5 K/+ 1 K to TSS. The distal region (D1/D2) was defined as +/− 100 K to TSS excluding the promoter region. PDLs were indicated with red lines. c The number of gained PDLs and differentially expressed genes (DEGs) with gained PDLs in MCF7-TamR cells. d The heatmap of gene expression of upregulated DEGs with gained PDLs

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