Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein(a) in 10,910 individuals

Table 2 Linear regression analysis between R21X carrier status and Lp(a) levels

Population	Carriers [n]	n	β*	95% CI lower bound*	95% CI upper bound*	SE*	p^†	R^2†	I^2\|\|
GCKD	74	4771	− 13.0^‡§	− 20.0	− 6.0	3.6	4.34e−12	0.011	–
KORA F3	56	3099	− 12.6	− 19.5	− 5.7	3.5	6.50e−11	0.013	–
KORA F4	63	3040	− 9.9	− 16.0	− 3.8	3.1	3.95e−12	0.015	–
Meta-analysis	193	10,910	− 11.7	− 15.5	− 7.8	1.9	3.39e−32	–	0.0

Lp(a) concentrations are given as mg/dL. The β estimate is given on the original scale (mg/dL). Age- and sex-adjusted model
n number
*On the original scale
^†On the inverse normal transformed scale
^‡GCKD additionally adjusted for eGFR: beta = − 12.4 [− 19.58; − 5.25], SE = 3.7, p = 3.16e−10
^§GCKD additionally adjusted for eGFR and urine albumin-to-creatinine ratio: beta = − 13.12 [− 20.22; − 6.02], SE = 3.6, p = 1.08e−10
^||Heterogeneity was 0.0 on the original and on the inverse normal transformed scales

ISSN: 1756-994X