Distribution of candidate disease genes and variants across families. a Overlap between CDGs in pairs of families. b Distribution of CDGs across families. The number of CDGs found in one, two, three, and 4–7 families is shown. c Distribution of alleles in CDGs found in three families (1-2-3, three different alleles; 1-1-2, two different alleles; 1-1-1, same allele found in all three families). d Distribution of alleles in CDGs shared in two families (1-2, different alleles; 1-1, same allele).