Skip to main content
Fig. 11 | Genome Medicine

Fig. 11

From: FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway

Fig. 11

Overview of the involvement of LINC00301 in NSCLC. Schematic representation of our proposed model of FOXC1 upregulates LINC00301 expression, the latter partially mediates oncogenic effects through its epigenetic silencing of EAF2 expression by directly binding with EZH2 to mediate HIF1α activation in the nucleus and by acting as ceRNA for miR-1276 to increase HIF1α expression in the cytoplasm in NSCLC

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us