Fig. 1
From: Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Molecular representativity of PDXs. OncoGenomic Landscape 2D representations of the molecular heterogeneity of the 187 PDXs annotated with both drug-response data and oncogenic alterations, compared with that of their corresponding reference cohorts of cancer patients from TCGA and MSKCC. The points represent the location of each individual PDX, colored by tumor type. The distribution of the 187 PDXs can be compared to the distribution of patient samples, represented as density color-scale map in the background: PanCancer, PAAD (pancreatic adenocarcinoma), COREAD (colorectal carcinoma), CM (cutaneous melanoma), NSCLC (non-small cell lung cancer), and BRCA (breast cancer). The boxplots show the proximity (median Jaccard similarity coefficient) of PDXs to the 5% nearest neighbors in each comparison. On the left, we show the clustering of PDXs based on tissue of origin by comparing the proximity of PDXs of a given tumor type among themselves and to PDXs of other tumor types. On the right, we show the clustering of PDXs with patient samples of the same tumor type compared to patient samples of other tumor types. Stars denote the p value of a Wilcoxon rank-sum test (*< 0.05, **< 0.01, ***< 0.001, and ****p value < 0.0001)