Fig. 2

Stop-gained and eQTL variants from GTEx show allele-specific regulatory effects on expression. a Effect size of non-eQTL control, eQTL, and stop-gained variants after editing with the polyclonal allelic expression assay. Triangular points mark variants whose effect sizes significantly deviate from the control distribution. b Correlation between the effect sizes of variants in GTEx and effect sizes from the polyclonal allelic expression assay. c Correlation between the effect sizes of variants in HEK293T cells and in HeLa cells from the polyclonal allelic expression assay. d eQTL effect size (aFC) in GTEx tissues for the 13 edited eQTL variants shown as boxplots, with lines indicating the median effect size in GTEx fibroblasts and in the assay. Asterisks mark variants which were significant in the assay in HEK293T cells