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Table 2 Differentially expressed genes (P = 6.41 × 10−4) within 1 Mb of differentially methylated CpGs

From: Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

EWAS CpG Chr:Position Number of genes within 1 Mb P value for TFAM methylation difference Gene P value for TFAM differential expression Direction of effect (following KO)* Distance from CpG (kb) Description
cg26094004 17:42,075,116 42 2.91E−05 IFI35 3.76E−05 Increased 931.6 Interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399]
RAMP2 5.51E−04 Increased 683.3 Receptor activity modifying protein 2 [Source:HGNC Symbol;Acc:HGNC:9844]
cg26563141 2:88,124,876 4 1.25E−02 RPIA 5.04E−06 Decreased 566.8 Ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297]
cg08899667 6:31,761,055 32 3.33E−03 HLA-DRB5 6.50E−07 Decreased 756.3 Major histocompatibility complex: class II: DR beta 5 [Source:HGNC Symbol;Acc:HGNC:4953]
MSH5 2.50E−04 Increased 1.8 mutS homolog 5 [Source:HGNC Symbol;Acc:HGNC:7328]
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