Table 2 Differentially expressed genes (P = 6.41 × 10−4) within 1 Mb of differentially methylated CpGs
EWAS CpG | Chr:Position | Number of genes within 1 Mb | P value for TFAM methylation difference | Gene | P value for TFAM differential expression | Direction of effect (following KO)* | Distance from CpG (kb) | Description |
|---|---|---|---|---|---|---|---|---|
cg26094004 | 17:42,075,116 | 42 | 2.91E−05 | IFI35 | 3.76E−05 | Increased | 931.6 | Interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] |
RAMP2 | 5.51E−04 | Increased | 683.3 | Receptor activity modifying protein 2 [Source:HGNC Symbol;Acc:HGNC:9844] | ||||
cg26563141 | 2:88,124,876 | 4 | 1.25E−02 | RPIA | 5.04E−06 | Decreased | 566.8 | Ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297] |
cg08899667 | 6:31,761,055 | 32 | 3.33E−03 | HLA-DRB5 | 6.50E−07 | Decreased | 756.3 | Major histocompatibility complex: class II: DR beta 5 [Source:HGNC Symbol;Acc:HGNC:4953] |
MSH5 | 2.50E−04 | Increased | 1.8 | mutS homolog 5 [Source:HGNC Symbol;Acc:HGNC:7328] |