Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

Table 2 Differentially expressed genes (P = 6.41 × 10⁻⁴) within 1 Mb of differentially methylated CpGs

EWAS CpG	Chr:Position	Number of genes within 1 Mb	P value for *TFAM* methylation difference	Gene	P value for *TFAM* differential expression	Direction of effect (following KO)*	Distance from CpG (kb)	Description
cg26094004	17:42,075,116	42	2.91E−05	IFI35	3.76E−05	Increased	931.6	Interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399]
cg26094004	17:42,075,116	42	2.91E−05	RAMP2	5.51E−04	Increased	683.3	Receptor activity modifying protein 2 [Source:HGNC Symbol;Acc:HGNC:9844]
cg26563141	2:88,124,876	4	1.25E−02	RPIA	5.04E−06	Decreased	566.8	Ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297]
cg08899667	6:31,761,055	32	3.33E−03	HLA-DRB5	6.50E−07	Decreased	756.3	Major histocompatibility complex: class II: DR beta 5 [Source:HGNC Symbol;Acc:HGNC:4953]
cg08899667	6:31,761,055	32	3.33E−03	MSH5	2.50E−04	Increased	1.8	mutS homolog 5 [Source:HGNC Symbol;Acc:HGNC:7328]

ISSN: 1756-994X