Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

Table 3 Summary of phenotype associations from all-cohort meta-analysis for Validated CpGs. Bold entries highlight nominally significant associations (P < 0.05). *Significant after stringent multiple test correction

All cohorts	Meta direction	Expected direction of phenotype association	Prevalent CHD			Prevalent CVD			Incident CHD			Incident CVD			Mortality
All cohorts	Meta direction	Expected direction of phenotype association	Beta	Std. Error	P value	Beta	Std. Error	P value	Beta	Std. Error	P value	Beta	Std. Error	P value	Beta	Std. Error	P value
cg21051031	Positive	Negative	−0.56	1.95	7.74E−01	−0.67	1.88	7.23E−01	0.96	1.80	5.94E−01	−0.28	1.41	8.43E−01	−0.79	0.81	3.31E−01
cg26094004	Negative	Positive	2.91	1.48	4.89E−02	3.13	1.40	2.55E−02	0.89	0.93	3.39E−01	−0.13	0.77	8.63E−01	−0.78	0.49	1.16E−01
cg26563141	Negative	Positive	0.22	1.33	8.69E−01	−0.31	1.24	8.00E−01	0.13	0.94	8.88E−01	1.10	0.75	1.40E−01	0.98	0.45	2.87E−02
cg14575356	Positive	Negative	−1.80	2.04	3.79E−01	−2.19	1.88	2.45E−01	2.71	1.34	4.36E−02	1.75	1.08	1.04E−01	0.12	0.68	8.63E−01
cg23513930	Positive	Negative	1.99	3.37	5.54E−01	0.88	3.07	7.75E−01	2.24	1.84	2.24E−01	0.50	1.49	7.39E−01	1.07	0.94	2.53E−01
cg08899667	Negative	Positive	3.65	1.76	3.81E−02	3.35	1.61	3.81E−02	1.57	1.10	1.54E−01	0.06	0.93	9.44E−01	2.08	0.59	3.93E−04*

ISSN: 1756-994X