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Table 3 Summary of phenotype associations from all-cohort meta-analysis for Validated CpGs. Bold entries highlight nominally significant associations (P < 0.05). *Significant after stringent multiple test correction

From: Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

All cohorts Meta direction Expected direction of phenotype association Prevalent CHD Prevalent CVD Incident CHD Incident CVD Mortality
Beta Std. Error P value Beta Std. Error P value Beta Std. Error P value Beta Std. Error P value Beta Std. Error P value
cg21051031 Positive Negative −0.56 1.95 7.74E−01 −0.67 1.88 7.23E−01 0.96 1.80 5.94E−01 −0.28 1.41 8.43E−01 −0.79 0.81 3.31E−01
cg26094004 Negative Positive 2.91 1.48 4.89E02 3.13 1.40 2.55E02 0.89 0.93 3.39E−01 −0.13 0.77 8.63E−01 −0.78 0.49 1.16E−01
cg26563141 Negative Positive 0.22 1.33 8.69E−01 −0.31 1.24 8.00E−01 0.13 0.94 8.88E−01 1.10 0.75 1.40E−01 0.98 0.45 2.87E02
cg14575356 Positive Negative −1.80 2.04 3.79E−01 −2.19 1.88 2.45E−01 2.71 1.34 4.36E02 1.75 1.08 1.04E−01 0.12 0.68 8.63E−01
cg23513930 Positive Negative 1.99 3.37 5.54E−01 0.88 3.07 7.75E−01 2.24 1.84 2.24E−01 0.50 1.49 7.39E−01 1.07 0.94 2.53E−01
cg08899667 Negative Positive 3.65 1.76 3.81E02 3.35 1.61 3.81E02 1.57 1.10 1.54E−01 0.06 0.93 9.44E−01 2.08 0.59 3.93E04*
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