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Fig. 1 | Genome Medicine

Fig. 1

From: The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Fig. 1

Workflow for the development, validation, and application of mMCP-counter. This figure depicts (1) the data acquisition, pre-processing, and normalization, as well as the mapping the cell population hierarchy; (2) the building of the methods by research and curation of cell-type-specific gene signatures and optimal scoring algorithm; (3) the validation of mMCP-counter by comparison to previously published methods on simulated mixtures and by comparison to immune composition inferred by flow-cytometry; and (4) the illustration of mMCP-counter to two datasets including mouse models of kidney cancer and mesothelioma treated by immune checkpoint blockade, and murine models of early neurodegeneration in Alzheimer’s disease

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