Fig. 5

mMCP-counter discriminates between tumor types and between responders and non-responders to immune checkpoint blockade. a Heatmap showing that clustering of tumors on mMCP-counter scores accurately separates tumors based on the tumor type (n = 24 mesothelioma models, n = 24 kidney cancer models, first line) and the response to immune checkpoint blockade (second line, n = 12 responders and n = 12 non-responders for each cancer type). The heatmap illustrates row Z-scores for all included cell populations. b Detailed differences in mMCP-counter scores between responders and non-responders to ICB in both kidney cancer and mesothelioma models. Comparisons are computed using Kruskal-Wallis tests followed by post hoc Dunn test for pairwise comparisons, with Benjamini-Hochberg correction for multiple testing. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. p ≥ 0.05