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Fig. 4 | Genome Medicine

Fig. 4

From: Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

Fig. 4

Cord blood ASD DMR genes are significantly enriched for epigenetically dysregulated genes in ASD brain. Gene sets significantly enriched among ASD DMR genes in both discovery and replication sample sets for either males or females (*q < 0.05). Heatmaps show odds ratios for enrichment in genes annotated to DMRs relative to genes annotated to background calculated with Fisher’s exact test for previously published studies of ASD and other neurological disorders. P values were adjusted using the false discovery rate (FDR) method for the total number of gene lists compared (pooled males TD n = 56, ASD n = 56; pooled females TD n = 20, ASD n = 20). Ac, acetylation; DEG, differentially expressed genes; Dup15, Chromosome 15q11-q13 Duplication syndrome; H3K27, histone 3 lysine 27; H3K4, histone 3 lysine 4; LCL, lymphoblastoid cell line; mCpG, CpG methylation; mCpH, CpH methylation; me3, trimethylation; PFC, prefrontal cortex; RTT, Rett syndrome; SFARI, Simons Foundation Autism Research Initiative

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Genome Medicine

ISSN: 1756-994X

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