Fig. 3

The cell of origin of HGSOC impacts the prognosis of patients independently of BRCA1/2 mutations. a Schematic representation of the strategy based on RNAseq to stratify a retrospective cohort of HGSOC. b Overall (left) and disease-free (right) survival of patients stratified by the cell of origin of HGSOC. Light-colored areas represent confidence intervals. Log rank test was used for statistical significance. c Cox’s proportional hazard model on clinical data. d Mutational status of BRCA1/2 in the retrospective cohort classified in FI-like (purple) and OSE-like (orange) tumors, shown as mutational frequency (top barplot) and contingency table (bottom). Fisher’s exact test was performed based on the contingency table. e Cumulative overall (left) and disease-free (right) survival over 5 years across the IEO, TCGA, and Tothill datasets. f Cox’s proportional hazard model on clinical data from the union of IEO, TCGA, and Tothill’s cohorts