Fig. 4

Gene expression patterns of OSE-like tumors reveal a lower inflammatory response coupled to increased survivability and active cell-to-cell signaling. a IPA causal network analysis performed on WGCNA eigengenes associated with OSE-like tumors. Blue: regulator genes whose pathway is predicted to be inhibited; orange: regulator genes whose pathway is predicted to be activated; red: upregulated eigengenes; green: downregulated eigengenes. b IPA disease and function enrichment analysis on WGCNA eigengenes associated with OSE-like tumors. Enrichment p values are shown after Benjamini-Hochberg FDR correction. c Treemap of three of the categories in b. Box dimension is derived on activation z-score. Enrichment p values are shown as in b. d The inflammatory response IPA disease and function enrichment analysis category predicted to be inhibited in OSE-like vs FI-like tumors