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Fig. 5 | Genome Medicine

Fig. 5

From: A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer

Fig. 5

OSE-like tumors have a mesenchymal, non-immunoreactive molecular phenotype. a Barplot of the mean expression levels of HGSOC molecular signatures in FI-like (purple bars) and OSE-like (orange bars) tumors. Two-way ANOVA analysis was used to calculate the significance for the difference in expression of the signature in the two groups. b Boxplot of the z-score relative to the expression of the mesenchymal (top) and immunoreactive (bottom) signatures in FI-like (purple) and OSE-like (orange) tumors. c Frequency stacked barplot for the proportion of Tothill’s molecular classes in FI-like and OSE-like tumors considering TCGA cohort (left panel) and Tothill’s cohort (right panel). The distribution in the entire considered dataset is reported on the rightmost bar of each panel (TCGA and Tothill, respectively)

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