Fig. 1

Cancer-specific relative enrichment of mutations in T cell-inflamed and non-T cell-inflamed tumors from known cancer driver genes. a Fifty-seven genes with mutation enrichment in one or more tumor types. Yellow and blue each represents genes preferably mutated in T cell-inflamed and non-T cell-inflamed tumors, respectively. Empty slots indicate a gene is not mutated in the tumor type. b Cancer-specific mutated genes that are preferably mutated in T cell-inflamed tumors (yellow) or non-T cell-inflamed tumors (blue). Coefficients of “mutation status” term from logistic regression models are shown on the x-axis, which describe the association between mutation status and tumor groups in the unit of logits. P values are shown on the y-axis. Each circle represents one gene in each tumor type. Out of 57 genes included in the analysis, those at FDR-adjusted P < 0.10 are shown in bold. For b, genes mutated in at least 5% of the samples in individual tumor types were included in statistical testing, hence shown on the volcano plots. Logistic regression with TMB as a covariate was used in b