Fig. 5

Multiple mutation- or pathway-mediated resistance mechanisms co-occur in non-T cell-inflamed tumors. a Co-occurrence of NSSMs in 29 genes from Fig. 3a at per patient level. Annotation bar above the heatmap indicates tumor type. b Co-activation of 31 transcriptional programs from Fig. 4a at per patient level. Annotation bar above the heatmap indicates tumor type. n = 3137 non-T cell-inflamed tumors are shown in a and b. The full list of co-mutated genes or co-activated pathways at per patient level is provided in Additional file 1: Table S12. c Percentage of tumor samples with one or more genes carrying NSSMs in the same patient from non-T cell-inflamed tumor group. NSSM score categories 0–10 are shown. Samples with more than 10 co-activated genes were collapsed into category 10. d Percentage of tumor samples with one or more transcriptional programs activated in the same patient from non-T cell-inflamed tumor group. Pathway score categories 0–10 are shown. Samples with more than 10 co-activated pathways were collapsed into category 10. The sample percentages and distance metrics are provided in Additional file 1: Table S14