Fig. 6
Interactions between co-activated pathways and T cell-inflamed gene expression. a Relationship between T cell-inflamed gene expression and increasing pathway scores. Each dot represents the median expression of the T cell-inflamed gene signature (shown on the y-axis) across samples in the score category (shown on the x-axis). Score categories with ≥ 10 samples were included in the analysis. Red line shows the linear regression model fitted with the observed data points (see the “Methods” section). Gray area indicates the 95% confidence interval. Adjusted R2 and P value are shown above each panel. The complete data and the regression models are provided in Additional file 1: Table S15. b Pathway network analysis shows connections between multiple transcriptional programs activated in non-T cell-inflamed tumors from one or more tumor types