Fig. 4From: The landscape of host genetic factors involved in immune response to common viral infectionsTranscriptome-wide association study (TWAS) results for continuous antigen response phenotypes. Two Manhattan plots depicting the associations for genes with a positive direction of effect (increased expression leads to higher antibody response) and genes with a negative direction of effect (increased expression is associated with a reduced antibody response). The threshold for statistical significance was determined based on the Bonferroni correction for the number of genes tested (P < 4.2 × 10−6, solid black line), while the suggestive significance threshold was set at P < 4.2 × 10−5 (dotted black line)Back to article page