Table 1 Lead genome-wide significant variants (P < 5.0 × 10⁻⁸) for continuous antibody response phenotypes for antigens with at least 20% seroprevalence

CMV

pp52

5000

6

32301427

rs115378818

C

T

0.978

0.633

(0.095)

2.9 × 10⁻¹¹

intronic

TSBP1

EBV

EA-D

6806

6

32665840

rs34825357

T

TC

0.409

− 0.114

(0.017)

2.0 × 10⁻¹¹

intergenic

MTCO3P1

EBV

EBNA

7003

3

151114852

rs67886110*

G

T

0.596

0.103

(0.017)

1.3 × 10⁻⁹

intronic

MED12L

6

32451762

rs9269233

A

C

0.249

0.315

(0.019)

3.5 × 10⁻⁶¹

intergenic

HLA-DRB9

EBV

VCA p18

7492

6

31486158

6:31486158

GT

G

0.245

0.197

(0.018)

7.1 × 10⁻²⁷

intergenic

PPIAP9

EBV

ZEBRA

7197

6

32637772

rs9274728

A

G

0.718

− 0.315

(0.018)

4.7 × 10⁻⁶⁷

intergenic

HLA-DQB1

HHV6

IE1A

6077

7

139985625

rs2429218

T

C

0.615

0.106

(0.019)

1.4 × 10⁻⁸

downstream

RP5-1136G2.1

HHV7

U14

7481

6

32602665

rs139299944

C

CT

0.655

0.114

(0.017)

1.5 × 10⁻¹¹

intronic

HLA-DQA1

11

118767564

rs75438046

G

A

0.970

0.280

(0.049)

1.3 × 10⁻⁸

3′-UTR

CXCR5 / BCL9L

17

45794706

rs1808192

A

G

0.331

− 0.099

(0.017)

9.8 × 10⁻⁹

intergenic

TBKBP1

HSV1

1gG

5468

6

32627852

rs1130420

G

A

0.583

− 0.122

(0.019)

2.5 × 10⁻¹⁰

3′-UTR

HLA-DQB1

10

91189187

rs11203123*

A

C

0.988

0.512

(0.093)

3.9 × 10⁻⁸

intergenic

SLC16A12

VZV

gE/Ig¹

7289

6

32623193

rs9273325

G

A

0.831

− 0.232

(0.021)

8.2 × 10⁻²⁸

intergenic

HLA-DQB1

BKV

VP1

7523

19

49206462

rs681343

C

T

0.491

− 0.125

(0.016)

4.7 × 10⁻¹⁵

synonymous

FUT2

JCV

VP1

4471

6

32589842

rs9271525

G

A

0.163

− 0.318

(0.031)

3.9 × 10⁻²⁴

intergenic

HLA-DQA1

MCV

VP1

5219

3

18238783

rs776170649

CT

C

0.790

− 0.134

(0.024)

1.7 × 10⁻⁸

intergenic

LOC339862

5

138865423

rs7444313

G

A

0.263

0.169

(0.021)

2.4 × 10⁻¹⁵

intergenic

TMEM173

6

32429277

rs9268847

A

G

0.750

− 0.195

(0.022)

2.4 × 10⁻¹⁹

intronic

HLA-DRB9