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Fig. 4 | Genome Medicine

Fig. 4

From: Best practices for variant calling in clinical sequencing

Fig. 4

Detecting somatic rearrangements in cancer using NGS. Shown is whole-genome sequencing data for chromosome 1 for a tumor-normal pair. Top: Log2 values indicate copy number changes in the tumor relative to the normal. Bottom: copy gains and losses skew tumor allele frequencies for heterozygous variants, with loss of heterozygosity (red) apparent in regions of heterozygous deletions

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