Fig. 4From: Best practices for variant calling in clinical sequencingDetecting somatic rearrangements in cancer using NGS. Shown is whole-genome sequencing data for chromosome 1 for a tumor-normal pair. Top: Log2 values indicate copy number changes in the tumor relative to the normal. Bottom: copy gains and losses skew tumor allele frequencies for heterozygous variants, with loss of heterozygosity (red) apparent in regions of heterozygous deletionsBack to article page