From: Best practices for variant calling in clinical sequencing
Strategy | Panel | Exome | Genome |
---|---|---|---|
Size of target space (Mbp) | ~ 0.5 | ~ 50 | ~ 3200 |
Average read depth | 500–100× | 100–150× | ~ 30–60× |
Relative cost | $ | $$ | $$$ |
SNV/indel detection | ++ | ++ | ++ |
CNV detection | + | + | ++ |
SV detection | – | – | + |
Low VAF | ++ | + | + |