Skip to main content
Fig. 2 | Genome Medicine

Fig. 2

From: MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era

Fig. 2

Maximum clade credibility tree of the S-type lineage. gCL10, the largest MDR cluster in Eswatini, has been circulating for 17.2 years prior to the DRS conducted in 2009–2010. Three different Rv0678 mutations occurred within this cluster. The M146T mutation was the most common (n = 21) and likely arose 6.7 years prior to the DRS. The N98D (n = 2) and G121R (n = 1) must have evolved within 5.5 and 7.8 years prior to the DRS, respectively. Isolates, for which BDQ and CFZ MICs were measured, are highlighted (Fig. 3 and Additional file 1: Table S3)

Back to article page