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Fig. 3 | Genome Medicine

Fig. 3

From: MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era

Fig. 3

Effect of Rv0678 mutations on BDQ and CFZ MICs. The MICs for the DS Beijing mutant with the Rv0678 A110V mutation were compared with those of 24 gCL10-outbreak MDR isolates with either the Rv0678 N98D, G121R, or M146T mutations (Fig. 2). The NCOFFs for the Rv0678 M146T distributions for CFZ (part a) and BDQ (part b) were set using the eyeball method, and a corresponding idealized representation of the MIC distributions of the gWT and Rv0678 M146T populations for both drugs (and their area of overlap in grey) was prepared for illustrative purposes (part c) [25]. The MIC increases for M146T relative to gWT isolates were statistically significant for both CFZ and BDQ. The Rv0678 G121R and A110V mutations could not be evaluated statistically as the mutations only appeared once

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