Fig. 4
EWAS candidate genes for weight-loss prediction. a ChromHMM prediction for all CpG sites which are significantly associated with weight changes during lifestyle intervention (P < 1 × 10–4).To identify putative target genes in the phenotype relevant target tissues: Intestine (Fetal-Intestine-Large, Fetal-Intestine-Small, Small-Intestines), Adipos-Nuclei (Adipose-Nuclei), Adipose Tissue (Adipose-Nuclei, Adipose-Derived-Mesenchymal-Stem-Cell-Cultured-Cells, Mesenchymal-Stem-Cell-Derived-Adipocyte-Cultured-Cells), Adipocytes (Mesenchymal-Stem-Cell-Derived-Adipocyte-Cultured-Cells), Adipocytes2 (Adipose-Derived-Mesenchymal-Stem-Cell-Cultured-Cells), Liver (Liver), Muscle (HSMM-cell-derived-Skeletal-Muscle-Myotubes-Cells, HSMM-Skeletal-Muscle-Myoblasts-Cells, Skeletal-Muscle-Female, Skeletal-Muscle-Male), and all (all 134 cells from Roadmap Epigenome Gateway). ChromHMM coding for TssA-active TSS, TssBiv-Bivalent (Poised) TSS, BivFlnk-Bivalent Flanking, EnhBiv-Bivalent Enhancer, ReprPC-Polycomb Repressed, ReprPCWk-Weakly Polycomb Repressed, Quies-Quiescent/low, TssAFlnk-Flanking TSS, TxFlnk-Flanking Transcribed, Tx-Transcribed, TxWk-Weakly Transcribed, EnhG- Genetic Enhancer, Enh –Enhancer, ZNF/Rpts-ZNF Genes and Repeats, He-Heterochromatin. b Receiver operating characteristic (ROC) curve for successful weight-loss under lifestyle intervention (for all males)