DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Table 2 Genetic regions discriminating responders from non-responders

Location	Adj.P	DeltaM	Probes/DMR	2D-KS_p value	SNPprobes	Cross-reactive probes	Genes	Probes/gene
chr10:134150449-134150761	2.4E−15	− 0.082275	8	5E−21	0	0	LRRC27	81
chr6:49681176-49681392	6.1E−11	0.101266	8	1.3E−16	0	0	CRISP2	14
chr17:33759510-33760309	0.0000054	0.083168	12	1.1E−11	0	0	SLFN12	22
chr13:21919004-21919171	0.000038	− 0.090555	3	7.9E−11	0	3	LINC00539	39
chr19:57742110-57742424	0.005	0.05827	9	0.000000011	0	0	AURKC	16
chr6:30039130-30039802	0.0077	− 0.114807	18	0.000000016	3	0	RNF39	83
chr12:311645-313379	0.0082	0.126218	9	0.000000017	1	0	RP11-283I3.2, SLC6A12	9.59
chr20:61371016-61371809	0.024	− 0.041995	5	0.000000051	3	0	NTSR1	38

Differentially methylated DMRs between responders and non-responders to lifestyle intervention; including all datasets at baseline and post-intervention. Top candidate DMRs with adj. P ≤ 0.05. DeltaM represents the difference of the mean average methylation rates between responders and non-responder as computed by metilene. The 2D-KS p value represents a two-dimensional variety of the Kolmogorov-Smirnov test used by metilene. Probes/DMR represents the number of probes within a DMR. SNPprobes represent probes containing a SNP with a frequency > 0.01. Cross-reactive probes indicate potential off-target probe binding. Genes is a comma-separated list of the genes cis to the DMR, and probes/gene is the total number of probes that are cis to the respective genes. Chromosomal location was annotated to genome assembly GRCh37 (hg19)

ISSN: 1756-994X