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Table 2 Genetic regions discriminating responders from non-responders

From: DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Location Adj.P DeltaM Probes/DMR 2D-KS_p value SNPprobes Cross-reactive probes Genes Probes/gene
chr10:134150449-134150761 2.4E−15 − 0.082275 8 5E−21 0 0 LRRC27 81
chr6:49681176-49681392 6.1E−11 0.101266 8 1.3E−16 0 0 CRISP2 14
chr17:33759510-33760309 0.0000054 0.083168 12 1.1E−11 0 0 SLFN12 22
chr13:21919004-21919171 0.000038 − 0.090555 3 7.9E−11 0 3 LINC00539 39
chr19:57742110-57742424 0.005 0.05827 9 0.000000011 0 0 AURKC 16
chr6:30039130-30039802 0.0077 − 0.114807 18 0.000000016 3 0 RNF39 83
chr12:311645-313379 0.0082 0.126218 9 0.000000017 1 0 RP11-283I3.2, SLC6A12 9.59
chr20:61371016-61371809 0.024 − 0.041995 5 0.000000051 3 0 NTSR1 38
  1. Differentially methylated DMRs between responders and non-responders to lifestyle intervention; including all datasets at baseline and post-intervention. Top candidate DMRs with adj. P ≤ 0.05. DeltaM represents the difference of the mean average methylation rates between responders and non-responder as computed by metilene. The 2D-KS p value represents a two-dimensional variety of the Kolmogorov-Smirnov test used by metilene. Probes/DMR represents the number of probes within a DMR. SNPprobes represent probes containing a SNP with a frequency > 0.01. Cross-reactive probes indicate potential off-target probe binding. Genes is a comma-separated list of the genes cis to the DMR, and probes/gene is the total number of probes that are cis to the respective genes. Chromosomal location was annotated to genome assembly GRCh37 (hg19)