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Table 3 Top EWAS hits for weight-change

From: DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Location

Combined_p value

Combined_correl

SNPprobes

Croscorr_probes

Genes

Probes/gene

chr9:128330232-128330233

2.13894E−06

0.415656804

0

0

RP11-12A16.3, MAPKAP1

4.87

chr20:48681452-48681453

2.89151E−06

0.410278561

0

0

.

 

chr20:30102074-30102075

3.64554E−06

0.40785049

0

0

HM13

51

chr8:47108510-47108511

7.25868E−06

0.396511089

0

0

.

 

chr16:85061578-85061579

9.60171E−06

− 0.390429782

0

0

KIAA0513

85

chr4:2860776-2860777

1.03553E−05

0.390219534

0

0

ADD1

60

chr1:10676746-10676747

1.10438E−05

0.38897137

1

0

RN7SL614P, PEX14

6.97

chr21:43995264-43995265

1.53041E-05

0.381354803

0

0

SLC37A1

92

chr1:155224863-155224864

1.65133E−05

0.382167212

0

0

FAM189B

22

chr14:24611228-24611229

1.66638E−05

0.381131462

0

0

EMC9

20

chr6:34312254-34312255

1.85412E−05

− 0.379666826

0

0

NUDT3, RPS10-NUDT3

40.55

chr3:39766166-39766167

2.68388E−05

− 0.369598821

1

0

.

 

chr16:32599433-32599434

2.95334E−05

0.36329876

1

1

.

 

chr14:23832577-23832578

3.0238E−05

− 0.370665738

0

0

EFS

19

chr2:43285304-43285305

3.60853E−05

− 0.367590736

0

0

.

 

chr5:74614787-74614788

3.80965E−05

0.365526726

0

0

.

 

chr14:19109264-19109265

3.95428E−05

0.365892373

1

1

RP11-754I20.1

6

chr10:35027638-35027639

3.97516E−05

0.36532732

0

0

PARD3

211

chr6:30009242-30009243

4.04387E−05

0.364775077

0

1

ZNRD1-AS1

223

chr1:151941392-151941393

4.22465E−05

0.363467421

1

0

.

 

chr7:30741951-30741952

4.41082E−05

0.362463879

0

0

INMT

39

chr20:58637969-58637970

4.4336E−05

0.362478499

0

0

C20orf197

16

chr8:25937278-25937279

4.62614E−05

0.362791545

0

0

.

 

chr18:76148676-76148677

4.88724E−05

0.361851294

1

0

.

 

chr12:96710026-96710027

4.89494E−05

0.360939508

0

1

CDK17

44

chr20:30947335-30947336

5.34863E−05

− 0.358758835

1

0

ASXL1

36

chr11:93884806-93884807

5.40302E−05

0.359319982

0

0

PANX1

38

chr12:69982015-69982016

5.77386E−05

0.35850731

0

0

CCT2

27

chr12:56837403-56837404

5.92256E−05

0.357960025

1

1

TIMELESS

21

chr22:31488064-31488065

5.93091E−05

0.357833796

0

0

SMTN

59

chr4:48508755-48508756

5.95427E−05

− 0.357497447

0

0

FRYL

74

chr4:186092824-186092825

6.24725E−05

−0.354276473

0

0

KIAA1430

40

chr2:232456125-232456126

6.63359E−05

0.354055051

0

0

C2orf57

7

chr19:51497512-51497513

6.73546E−05

0.355569746

0

0

CTB-147C22.9

59

chr2:202507599-202507600

7.31631E−05

0.35259332

0

0

TMEM237

27

chr16:66914802-66914803

8.20107E−05

− 0.351288405

0

0

PDP2

27

chr13:114201583-114201584

8.30031E−05

0.350644678

0

0

TMCO3

108

chr7:1694822-1694823

8.61102E−05

0.350667814

0

0

.

 

chr1:84763932-84763933

8.75277E−05

− 0.35001248

0

0

SAMD13

37

chr5:86563580-86563581

8.79946E-05

− 0.346433913

0

0

RASA1

46

chr11:1220228-1220229

8.93413E−05

− 0.349897083

0

0

MUC5AC

49

chr8:117864506-117864507

9.16977E−05

− 0.349138937

0

0

RAD21

39

chr5:52929435-52929436

9.18704E−05

0.348561794

0

0

NDUFS4

31

chr12:124808992-124808993

9.7238E−05

− 0.348213686

1

0

NCOR2

334

chr6:100483904-100483905

9.74908E−05

0.348082518

0

0

MCHR2-AS1

23

chr1:110753895-110753896

9.93168E−05

0.343588975

0

0

KCNC4-AS1, KCNC4

19.47

chr11:117054853-117054854

9.94225E−05

− 0.347463234

0

0

SIDT2

34

  1. The table presents the top CpG sites (P ≤ 1 × 10−4) from combined Spearman and Pearson correlation analysis of genome-wide DNA methylation at baseline with relative changes (+/−) in body weight after intervention. Combined P value represents geometric mean of Spearman and Pearson correlation P values. SNPprobes represent probes containing a SNP with a frequency > 0.01. Cross-reactive probes indicate potential off-target probe binding. Genes is a comma-separated list of the genes cis to the CpG. Chromosomal location was annotated to genome assembly GRCh37 (hg19)