Skip to main content

Table 3 Top EWAS hits for weight-change

From: DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Location Combined_p value Combined_correl SNPprobes Croscorr_probes Genes Probes/gene
chr9:128330232-128330233 2.13894E−06 0.415656804 0 0 RP11-12A16.3, MAPKAP1 4.87
chr20:48681452-48681453 2.89151E−06 0.410278561 0 0 .  
chr20:30102074-30102075 3.64554E−06 0.40785049 0 0 HM13 51
chr8:47108510-47108511 7.25868E−06 0.396511089 0 0 .  
chr16:85061578-85061579 9.60171E−06 − 0.390429782 0 0 KIAA0513 85
chr4:2860776-2860777 1.03553E−05 0.390219534 0 0 ADD1 60
chr1:10676746-10676747 1.10438E−05 0.38897137 1 0 RN7SL614P, PEX14 6.97
chr21:43995264-43995265 1.53041E-05 0.381354803 0 0 SLC37A1 92
chr1:155224863-155224864 1.65133E−05 0.382167212 0 0 FAM189B 22
chr14:24611228-24611229 1.66638E−05 0.381131462 0 0 EMC9 20
chr6:34312254-34312255 1.85412E−05 − 0.379666826 0 0 NUDT3, RPS10-NUDT3 40.55
chr3:39766166-39766167 2.68388E−05 − 0.369598821 1 0 .  
chr16:32599433-32599434 2.95334E−05 0.36329876 1 1 .  
chr14:23832577-23832578 3.0238E−05 − 0.370665738 0 0 EFS 19
chr2:43285304-43285305 3.60853E−05 − 0.367590736 0 0 .  
chr5:74614787-74614788 3.80965E−05 0.365526726 0 0 .  
chr14:19109264-19109265 3.95428E−05 0.365892373 1 1 RP11-754I20.1 6
chr10:35027638-35027639 3.97516E−05 0.36532732 0 0 PARD3 211
chr6:30009242-30009243 4.04387E−05 0.364775077 0 1 ZNRD1-AS1 223
chr1:151941392-151941393 4.22465E−05 0.363467421 1 0 .  
chr7:30741951-30741952 4.41082E−05 0.362463879 0 0 INMT 39
chr20:58637969-58637970 4.4336E−05 0.362478499 0 0 C20orf197 16
chr8:25937278-25937279 4.62614E−05 0.362791545 0 0 .  
chr18:76148676-76148677 4.88724E−05 0.361851294 1 0 .  
chr12:96710026-96710027 4.89494E−05 0.360939508 0 1 CDK17 44
chr20:30947335-30947336 5.34863E−05 − 0.358758835 1 0 ASXL1 36
chr11:93884806-93884807 5.40302E−05 0.359319982 0 0 PANX1 38
chr12:69982015-69982016 5.77386E−05 0.35850731 0 0 CCT2 27
chr12:56837403-56837404 5.92256E−05 0.357960025 1 1 TIMELESS 21
chr22:31488064-31488065 5.93091E−05 0.357833796 0 0 SMTN 59
chr4:48508755-48508756 5.95427E−05 − 0.357497447 0 0 FRYL 74
chr4:186092824-186092825 6.24725E−05 −0.354276473 0 0 KIAA1430 40
chr2:232456125-232456126 6.63359E−05 0.354055051 0 0 C2orf57 7
chr19:51497512-51497513 6.73546E−05 0.355569746 0 0 CTB-147C22.9 59
chr2:202507599-202507600 7.31631E−05 0.35259332 0 0 TMEM237 27
chr16:66914802-66914803 8.20107E−05 − 0.351288405 0 0 PDP2 27
chr13:114201583-114201584 8.30031E−05 0.350644678 0 0 TMCO3 108
chr7:1694822-1694823 8.61102E−05 0.350667814 0 0 .  
chr1:84763932-84763933 8.75277E−05 − 0.35001248 0 0 SAMD13 37
chr5:86563580-86563581 8.79946E-05 − 0.346433913 0 0 RASA1 46
chr11:1220228-1220229 8.93413E−05 − 0.349897083 0 0 MUC5AC 49
chr8:117864506-117864507 9.16977E−05 − 0.349138937 0 0 RAD21 39
chr5:52929435-52929436 9.18704E−05 0.348561794 0 0 NDUFS4 31
chr12:124808992-124808993 9.7238E−05 − 0.348213686 1 0 NCOR2 334
chr6:100483904-100483905 9.74908E−05 0.348082518 0 0 MCHR2-AS1 23
chr1:110753895-110753896 9.93168E−05 0.343588975 0 0 KCNC4-AS1, KCNC4 19.47
chr11:117054853-117054854 9.94225E−05 − 0.347463234 0 0 SIDT2 34
  1. The table presents the top CpG sites (P ≤ 1 × 10−4) from combined Spearman and Pearson correlation analysis of genome-wide DNA methylation at baseline with relative changes (+/−) in body weight after intervention. Combined P value represents geometric mean of Spearman and Pearson correlation P values. SNPprobes represent probes containing a SNP with a frequency > 0.01. Cross-reactive probes indicate potential off-target probe binding. Genes is a comma-separated list of the genes cis to the CpG. Chromosomal location was annotated to genome assembly GRCh37 (hg19)