Fig. 2

Aberrant expression of HSPs in cancer. a Expression alterations of HSPs between tumor and paired normal tissue samples across cancer types. Histogram height denotes the number of cancer types with differentially expressed HSPs. Dots denote upregulation (red) and downregulation (blue). Dots with black edges denote significant difference (|FC| > 1.5 and FDR < 0.05). Multi-colored bar in the middle panel denotes HSP families. b Clinically relevant HSPs across human cancers. Colored cells in outer circle denote significant events. Colored bars in middle circle denote numbers of significant cases. Red, blue, green, and yellow denote significant cases in grade, stage, subtype, and survival. Inner circle denotes HSP families